PROGRAMME   MONDAY 26 MARCH 2012   10.30 Opening of the 3rd TNO Beneficial Microbes Conference   10.45 Keynote lecture Setting the scene: How to define a beneficial microbe? Prof.dr. Eric Claassen, VU University Amsterdam / Erasmus MC, the Netherlands     Session 1 Beneficial microbes and host-microbe communication   Chair: Prof.dr. Jerry Wells Wageningen University, the Netherlands   11.15 Gate-keeper function of the epithelium Prof.dr. Per Brandtzaeg, University of Oslo and Oslo University Hospital, Norway   11.45 Inter-kingdom chemical signalling in host-bacterial associations Dr. Vanessa Sperandio, University of Texas Southwestern Medical Center, USA   12.15 Probiotic mechanism to enhance influenza vaccination Dr. Marjolein Meijerink, Host-Microbe Interactomics, Wageningen UR, the Netherlands   12.45 Contributed paper Antimicrobial functions of intestinal Reg3ß Linda Loonen, M.Sc., TI Food & Nutrition / Wageningen UR, the Netherlands     13.00 - 14.00 Lunch break   Session 2 Effect of beneficial microbe metabolites on the host   Chair: Dr. Ger Rijkers University College Roosevelt Academy, the Netherlands   14.00 Function and importance of Akkermansia spp. in the intestinal tract Clara Belzer, Laboratory of Microbiology, Wageningen UR, the Netherlands   14.30 Effect of propionate on adipose metabolism Dr. Koen Venema, TNO Healthy Living, the Netherlands   15.00 Administration of butyrate producing organisms to treat IBD Dr. Hana Kozáková, Institute of Microbiology, Academy of Sciences, Czech Republic   15.30 Contributed paper Lactate produced by Streptococcus thermophilus in intestinal tract of gnotobiotic rats may trigger goblet cells differentiation pathway: a new probiotic function? Laura Wrzosek, Commensal and Probiotics-Host Interactions Laboratory, INRA, France   15.45 Networking break     Session 3 Shaping and modulating microbiotia composition   Chair: Dr. Annick Mercenier Nestlé Research Center, Switzerland   16.15 Evolution of the microbiota and the influence of diet Prof.dr. Michael Blaut, German Institute of Human Nutrition Potsdam-Rehbruecke, Germany   16.45 Breast milk – the source of more life than we imagine Dr. Rocio Martin, Danone Research, the Netherlands   17.15 A novel approach to microbial replacement: 30 strain transplant Dr. Elaine Petrof, Oueen's University, Canada   17.45 Functional foods for digestive health in dogs Dr. Julie K. Spears, Nestlé Purina PetCare, USA   18.15 Contributed paper The ontogeny of the intestinal IgA CDR3 repertoire and IgA production in response to the gut microbiota Gerco den Hartog, Cell Biology and Immunology Group/Adaptation Physiology Group, Wageningen UR, the Netherlands     18.30 - 19.30 TNO's Lounge Party TUESDAY 27 MARCH 2012 Session 4 Mining the metagenome and microbiome of the gut   Chair: Dr. Jiro Nakayama Kyushu University, Japan   08.30 Tools to display metagenomics data William A. Walters, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, USA   09.00 Metagenomics screening (MetaHit) Dr. S. Dusko Ehrlich, MICA Department, INRA, France and Académie des Arts et Sciences, Croatia   09.30 Asian Microbiome Project: A pilot study on the basal microbiota profile of healthy youngsters Dr. Yuan Kun Lee, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore   10.00 Contributed paper A multiscale systems biology approach to the human Bacteroides thetaiotaomicron Dr. Ines Thiele, Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, University of Iceland, Iceland   10.15 Networking break     Session 5 Can beneficial microbes prevent diseases?   Chair: Prof.dr. Michael Cabana University of California, San Fransisco, USA   10.45 Bifidobacteria protect the host from enteropathogenic infection through production of acetate Dr. Hiroshi Ohno, Research Center for Allergy and Immunology, RIKEN, Japan   11.10 Beneficial microbes – the link between diet and cancer risk? Dr. Wendy S. Garrett, Department of Immunology and Infectious Diseases, Harvard School of Public Health and Dana-Farber Cancer Institute, USA   11.35 Intestinal dysbiosis in coeliac disease: is there a role for probiotics? Dr. Yolanda Sanz, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Spain   12.00 The airway microbiome in asthma and COPD Yvonne J. Huang, Department of Medicine, University of California, San Francisco, USA   12.25 Contributed paper Influence of human gut microbiota on the metabolic fate of glucosinolates Vijitra Luang-In, Department of Life Sciences, Imperial College London, UK     12.40 - 13.30 Lunch break Session 6 Validated in vitro and ex vivo models   Chair: Dr. Koen Venema TNO, the Netherlands   13.30 Organotypic co-culture models to study the effect of beneficial microbes functionally Dr. Manfred Schmolz, EDI GmbH, Germany   14.00 Use of an in vitro model to study fermentation by the microbiota Dr. Marjorie Koenen, TNO, the Netherlands   14.30 Assessment of survival of probiotics under various conditions using a validated in vitro model Thomas D. Leser, Chr. Hansen A/S, Health & Nutrition Division, Denmark   15.00 A novel polarized ex vivo organ culture model to study beneficial microbes Dr. Katerina Tsilingiri, Department of Experimental Oncology, European Institute of Oncology, Italy   15.30 Contributed paper Glycerol supplementation boots Lactobacillus reuteri's protective effect against Salmonella typhimurium infection in a 3-D organotypic model of colon epithelium Rosemarie De Weirdt, Laboratory of Microbial Ecology and Technology, Ghent University, Belgium   15.45 Networking break     Session 7 Towards successful claims for pre-and probiotics   Chair: Dr. Gregor Reid University of Western Ontario, Canada   16.15 Beneficial microbes: claims and ethics Dr. Diane Hoffmann, School of Law, University of Maryland, USA   16.45 Critical issues for successful claim applications Dr. Alwine Kardinaal, TNO, the Netherlands   17.15 Why do we need claims on products? Consumers don't!? Dr. Ger Rijkers, University College Roosevelt Academy, the Netherlands   17.45 Contributed paper Primo-colonizing bacteria induce maturation of colonic epithelium in gnotobiotic rat models Dr. Claire Cherbuy, Commensal and Probiotics-Host Interactions Laboratory, INRA, France     18.00 - 19.30 Drinks during poster presentations 20.30 Conference dinner   WEDNESDAY 28 MARCH 2012 Session 8 Recent successful applications of beneficial microbes   Chair: Dr. Frédérique Chaucheyras-Durand Lallemand, France   08.30 Microbial mitigation: the Achilles' heel of allergy? Prof.dr. Harry Wichers, Food & Biobased Research, Wageningen UR, the Netherlands   08.50 Effect of B. breve Yakult on childhood constipation – a case study Eline van Bel, Waterland Hospital, the Netherlands   09.10 Probiotics for HIV subjects in the developing world Dr. Gregor Reid, Lawson Health Research Institute and University of Western Ontario, Canada   09.30 Control of bacterial diseases in aquaculture with pre- and probiotics Prof.dr. Peter Bossier, Laboratory of Aquaculture & Artemia Reference Center, Department of Animal Production, Ghent University, Belgium   09.50 Live yeast probiotics and immunomodulation in pigs Dr. Kenneth Mellits, Division of Food Science, School of Biosciences, University of Nottingham, UK   10.10 Contributed paper Influence of probiotics on the intestinal epithelial barrier Dr. Saskia van Hemert, Winclove, the Netherlands   10.30 Networking break     Session 9 Future developments – new tools   Chair: Dr. Koen Venema TNO, the Netherlands   11.00 Drosophila as a model system to study microbiota/gut interaction Prof. Dr. Julien Royet, Developmental Biology Institute of Marseilles – Luminy, CNRS, France   11.30 A microfluidic platform for droplet-enabled co-cultivation of microbial communities Jihyang Park, M.Sc., University of Michigan, USA   12.00 Single cell genomic sequencing of uncultured bacteria for the human microbiome project Prof.dr. Roger Lasken, J. Craig Venter Institute, USA   12.30 From stem-cells to self-organizing organoids Prof.dr. Hans Clevers, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, the Netherlands   13.00 Closing of the 3rd TNO Beneficial Microbes Conference (including a packed lunch to eat along the way!)

 

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